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Oxycodone is a semi-synthetic opiate manufactured by modifying the chemical thebaine,
an organic chemical found in opium.1
It is the active ingredient in a number of
commonly prescribed pain relief medications such as Percocet, Percodan, and Tylox.
Each of these contains oxycodone in small doses combined with other active ingredients
like aspirin.2
OxyContin, another prescription form of oxycodone, is available in doses
ranging in strength from 10mg to 80mg tablets. Intended use of OxyContin is for longterm
relief (up to 12 hours) of moderate to severe pain associated with conditions such as
cancer and arthritis.3
A unique property of OxyContin is that the tablets are time
released; that is, the effects of the drug and its analgesic properties take effect over a set
period of time rather than all at once. It is similar to codeine and methadone in its
analgesic (pain-killing) properties


oxycodone indicated for the management of pain severe enough to require daily, aroundthe-clock,
long-term opioid treatment and for which alternative treatment options are inadequate
• Adults; and
• Opioid-tolerant pediatric patients 11 years of age and older who are already receiving
and tolerate a minimum daily opioid dose of at least 20 mg oxycodone orally or its

How to take

Oxycodone products can be administered intramuscularly (injection directly into the
muscle), intravenously (injection into the blood stream), subcutaneously (injection under
the skin), rectally, and/or orally through pills and tablets.13 OxyContin, taken orally (in
tablet form), can remain effective for up to 12 hours, making it the longest acting
oxycodone product available. While legal doses vary by patient, a typical dose
prescribed by a physician ranges from two to four tablets daily. Currently there are four
dosages available – 10, 20, 40, and 80mg tablets. The 160mg tablet (available in 2000)
was suspended in May 2001 due to its severe abuse potential.14 Those who abuse the
drug generally do so in three different ways: crushing the pill into a fine powder and
snorting it; chewing it; or crushing and dissolving the tablets in water and injecting the
solution. Many of these methods are primarily used with OxyContin in order to defeat
the time-release mechanism of the drug, causing the active ingredient to take effect
almost immediately after ingestion. When using OxyContin this way, the risk of an
overdose increases dramatically since the drug is not intended to be used in this manner.
Some users also mix the drug with alcohol to achieve an even greater high15, even though
it can be a fatal combination.

Side effects

When using oxycodone products, including OxyContin, under the care of a physician,
most users will experience mild side effects. Like many other narcotic medications,
oxycodone can impair certain daily activities, such as driving and other mental and
physical abilities. These side effects are usually mild, but there are more serious
complications and negative effects from using products containing oxycodone,
particularly when abused.
Side effects of oxycodone products include:
• Breathing irregularity or respiratory depression
• Increased pressure of cerebral and spinal fluid
• Headaches
• Nausea
• Dizziness
• Heart failure
• Low blood pressure
• Overdose death due to cardiac arrest or slowed breathing (especially when
ingesting crushed OxyContin tablets)

Learn more here


The chemical structure of oxycodone is similar to another pain reliever – codeine – and is
almost as potent as morphine in its ability to produce opiate-like effects.16 Oxycodone
works by binding to the pain receptors in the brain so that the sensation of pain is
reduced.17 In other words, it attempts to change pain messages being sent to the brain so
the user will be relieved of moderate to severe or chronic pain linked to such conditions
as cancer and arthritis. Illicit users ingest the drug for a number of reasons. Some use it
to control withdrawal symptoms of heroin or morphine18, while others use and/or abuse
the drug only in an attempt to achieve a euphoric high.


oxycodone is contraindicated in patients with:
• Significant respiratory depression
• Acute or severe bronchial asthma in an unmonitored setting or in the absence of

resuscitative equipment

• Known or suspected paralytic ileus and gastrointestinal obstruction
• Hypersensitivity (e.g., anaphylaxis) to oxycodone

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